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X-Ray Excited Luminescence Spectroscopy and Imaging with NaGdF4:Eu and Tb

preprint
submitted on 02.11.2020, 05:18 and posted on 03.11.2020, 09:08 by Meenakshi Ranasinghe, Md Arifuzzaman, Apeksha C. Rajamanthrilage, Ashley Dickey, Joseph W. Kolis, Mark Bolding, Jeffrey Anker

X-ray scintillating NaGdF4: Eu and Tb nanophosphors were synthesized via co-precipitate and hydrothermal methods, encapsulated with silica, functionalized with biotin, and characterized by X-ray excited optical luminescence spectroscopy and imaging. The nanophosphors synthesized by co-precipitate method were ~90 and ~106 nm in size, respectively; nanophosphors synthesized by hydrothermal method showed the highest luminescence intensity. Further, we investigated the effect of thermal annealing/calcination on the X-ray excited luminescence spectra and intensity. We observed, at high-temperature, NaGdF4: Eu@SiO2 converts to NaGd9Si6O26: Eu which is also an X-ray scintillator. The particles generate light through tissue and can be selectively excited using a focused X-ray source for imaging and light generation applications. The particles also act as MRI contrast agents for multi-modal localization.

History

Email Address of Submitting Author

mranasi@g.clemson.edu

Institution

Clemson University

Country

United States

ORCID For Submitting Author

0000-0002-0858-1298

Declaration of Conflict of Interest

no conflict of interest

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