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Architectured helically coiled scaffolds from elastomeric poly(butylene succinate) (PBS) copolyester via wet electrospinning

preprint
revised on 25.09.2019, 13:02 and posted on 26.09.2019, 15:06 by Agueda Sonseca, Rahul Sahay, Karolina Stepien, Julia Bukała, Aleksandra Wcislek, Andrew McClain, Peter Sobolewski, XiaoMeng Sui, Judit E. Puskas, Joachim Kohn, H. Daniel Wagner, Miroslawa El Fray

Electrospinning is one of the most investigated methods used to produce polymeric fiber structures that mimic the morphology of native extracellular matrix. These structures have been extensively studied in the context of scaffolds for tissue regeneration. However, the compactness of materials obtained by traditional electrospinning, collected as two-dimensional non-woven scaffolds, can limit cell infiltration and tissue ingrowth. In addition, for applications in smooth muscle tissue engineering, highly elastic scaffolds capable of withstanding cyclic mechanical strains without suffering significant permanent deformations are preferred. In order to address these challenges, we report the fabrication of microscale 3D helically coiled structures (referred as 3D-HCS) by wet-electrospinning method, a modification of the traditional electrospinning process in which a coagulation bath (non-solvent system for the electrospun material) is used as the collector. The present study, for the first time, successfully demonstrates the feasibility of using this method to produce various architectures of 3D-HCS from segmented copolyester of poly(butylene succinate-co- dilinoleic succinate) (PBS-DLS), a thermoplastic elastomer. A mechanism for the HCS formation is proposed and verified with experimental data. Fabricated 3D-HCS showed high specific surface area, high porosity, and good elasticity. Further, the marked increase in cell proliferation on 3D-HCS confirmed the suitability of these materials as scaffolds for soft tissue engineering.

Funding

National Science Centre, Poland, under the HARMONIA scheme (agreement No. UMO-2014/14/M/ST8/00610)

History

Email Address of Submitting Author

psobolewski@zut.edu.pl

Institution

Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology, Szczecin

Country

Poland

ORCID For Submitting Author

0000-0002-2097-0990

Declaration of Conflict of Interest

no conflict of interest

Version Notes

Corrected errors; edited for clarity; expanded details of characterization methods; improved discussion of electrospinning jet regimes

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