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is a ubiquitous cytoskeletal protein, forming a dynamic network that generates
mechanical forces in the cell. Here, in order to dissect the complex mechanisms
of actin-related cellular functions, we introduce two powerful tools based on a
new class of actin-binding small molecule: one enables visualization of the
actin cytoskeleton, including super-resolution imaging, and the other enables
highly specific green-light-controlled fragmentation of actin filaments,
affording unprecedented control of the actin cytoskeleton and its force network
in living cells.