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Visible Light-Induced Sulfonylation/Arylation of Styrenes in a Double Radical Three-Component Photoredox Reaction

preprint
submitted on 14.02.2019 and posted on 15.02.2019 by Benjamin Lipp, Lisa Marie Kammer, Murat Kucukdisli, Adriana Luque, Jonas Kühlborn, Stefan Pusch, Gita Matulevičiūtė, Dieter Schollmeyer, Algirdas Šačkus, Till Opatz
Simultaneous sulfonylation/arylation of styrene derivatives is achieved in a photoredox-catalyzed three-component reaction using visible light. A broad variety of difunctionalized products is accessible in mostly excellent yields and high diastereoselectivity. The developed reaction is scalable and suitable for the modification of styrene-functionalized biomolecules. Mechanistic investigations suggest the transformation to be operating through a designed sequence of radical formation and radical combination.

Funding

Studienstiftung des deutschen Volkes

Deutsche Forschungsgemeinschaft

ERASMUS programme

LESSING initiative of Johannes Gutenberg University

History

Email Address of Submitting Author

opatz@uni-mainz.de

Institution

Johannes Gutenberg University

Country

Germany

ORCID For Submitting Author

0000-0002-3266-4050

Declaration of Conflict of Interest

No conflict of interest to declare

Version Notes

Version submitted on February 06, 2019, uploaded to ChemRxiv on February 14, 2019

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