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Visible Light-Induced Sulfonylation/Arylation of Styrenes in a Double Radical Three-Component Photoredox Reaction

submitted on 14.02.2019, 20:46 and posted on 15.02.2019, 20:40 by Benjamin Lipp, Lisa Marie Kammer, Murat Kucukdisli, Adriana Luque, Jonas Kühlborn, Stefan Pusch, Gita Matulevičiūtė, Dieter Schollmeyer, Algirdas Šačkus, Till Opatz
Simultaneous sulfonylation/arylation of styrene derivatives is achieved in a photoredox-catalyzed three-component reaction using visible light. A broad variety of difunctionalized products is accessible in mostly excellent yields and high diastereoselectivity. The developed reaction is scalable and suitable for the modification of styrene-functionalized biomolecules. Mechanistic investigations suggest the transformation to be operating through a designed sequence of radical formation and radical combination.


Studienstiftung des deutschen Volkes

Deutsche Forschungsgemeinschaft

ERASMUS programme

LESSING initiative of Johannes Gutenberg University


Email Address of Submitting Author


Johannes Gutenberg University



ORCID For Submitting Author


Declaration of Conflict of Interest

No conflict of interest to declare

Version Notes

Version submitted on February 06, 2019, uploaded to ChemRxiv on February 14, 2019