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Visible Light-Induced Sulfonylation/Arylation of Styrenes in a Double Radical Three-Component Photoredox Reaction

preprint
submitted on 14.02.2019, 20:46 and posted on 15.02.2019, 20:40 by Benjamin Lipp, Lisa Marie Kammer, Murat Kucukdisli, Adriana Luque, Jonas Kühlborn, Stefan Pusch, Gita Matulevičiūtė, Dieter Schollmeyer, Algirdas Šačkus, Till Opatz
Simultaneous sulfonylation/arylation of styrene derivatives is achieved in a photoredox-catalyzed three-component reaction using visible light. A broad variety of difunctionalized products is accessible in mostly excellent yields and high diastereoselectivity. The developed reaction is scalable and suitable for the modification of styrene-functionalized biomolecules. Mechanistic investigations suggest the transformation to be operating through a designed sequence of radical formation and radical combination.

Funding

Studienstiftung des deutschen Volkes

Deutsche Forschungsgemeinschaft

ERASMUS programme

LESSING initiative of Johannes Gutenberg University

History

Email Address of Submitting Author

opatz@uni-mainz.de

Institution

Johannes Gutenberg University

Country

Germany

ORCID For Submitting Author

0000-0002-3266-4050

Declaration of Conflict of Interest

No conflict of interest to declare

Version Notes

Version submitted on February 06, 2019, uploaded to ChemRxiv on February 14, 2019

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