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Visible-Light Photosensitized Aryl and Alkyl Decarboxylative Carbon-Heteroatom and Carbon-Carbon Bond Formations

preprint
revised on 22.04.2019 and posted on 23.04.2019 by Frank Glorius, Tuhin Patra, Satobhisha Mukherjee, Jiajia Ma, Felix Strieth-Kalthoff
A general strategy to access both aryl and alkyl radicals by photosensitized decarboxylation of the corresponding carboxylic acids esters has been developed. An energy transfer mediated homolysis of unsymmetrical sigma-bonds for a concerted fragmentation/decarboxylation process is involved. As a result, an independent aryl/alkyl radical generation step enables a series of key C-X and C-C bond forming reactions by simply changing the radical trapping agent.

Funding

Alexander von Humboldt Foundation (postdoctoral funding for TP)

Deutsche Forschungsgemeinschaft (SFB858 and Leibniz Award to FG)

History

Email Address of Submitting Author

glorius@uni-muenster.de

Institution

University of Muenster

Country

Germany

ORCID For Submitting Author

0000-0002-0648-956X

Declaration of Conflict of Interest

None.

Exports