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lesh step.pdf (2.09 MB)

Virtual Screening of Leishmanial Pyridoxal Kinase Enzyme Inhibitors by Repurposed Anti-Trypanosomal Libraries Reveals Two Core Scaffolds

preprint
submitted on 10.10.2020 and posted on 13.10.2020 by Sanad Alfadhel
Leishmania is an intracellular protozoal infection, and it is classified as a neglected disease by the World Health Organization (WHO). Annually more than 2 million newly diagnosed cases were treated with highly toxic drugs. Leishmanial pyridoxal kinase enzyme (LPDxK) is an essential and druggable target. DNDI1103666 is the most promising lead as a potential inhibitor for LPDxK

History

Email Address of Submitting Author

sanad.alfadhel@alkafeel.edu.iq

Institution

alkafeel university

Country

Iraq

ORCID For Submitting Author

0000-0001-8092-8607

Declaration of Conflict of Interest

no conflict of interest

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