Utilizing Carbonyl-Coordination of Native Amides for Pd– catalyzed C(sp3)–H Olefination
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Pd(II)–catalyzed C(sp3)–H olefination of native amide substrates was developed. To utilize the extremely
weak-coordinating carbonyl-coordination of amides, an electron-deficient pyridinesulfonic acid ligand
was designed. Structurally diverse amide substrates, including lactams, underwent olefination without the
undesired cyclization. Olefination products were further diversified through synthetic transformations on
the alkenyl moiety.