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Vercruysse_Chem Preprint_anti-oxidant studies using melanogenesis.pdf (539.94 kB)
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submitted on 16.12.2018 and posted on 17.12.2018by Koen Vercruysse, Iesha Brown, Sha'Kendria Summers
Building upon our research on the non-enzymatic
synthesis of melanins, we explored the possibility that the reactions involved
in the synthesis of melanins could serve as the basis for the study of and
search for compounds with anti-oxidant properties. The synthesis of melanins can
be achieved through air-mediated oxidation or through
reactive-oxygen-species-mediated oxidation and can readily be monitored by the
changes in color. In addition, a broad variety of different precursors can be
used to generate melanins. Thus, using melanogenesis as the foundation for an
anti-oxidant assay, one can evaluate the effects of potential anti-oxidants
against air- or reactive-oxygen-species mediated oxidations and evaluate the
consistency of the anti-oxidant effects when different precursors for
melanogenesis are used.