ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
0/0

Using Alcohols As Simple H2-Equivalents for Copper-Catalysed Transfer Hydrogenations

preprint
submitted on 26.08.2019 and posted on 27.08.2019 by Trinadh Kaicharla, Birte Zimmermann, Martin Oestreich, Johannes F. Teichert
Catalytic transfer hydrogenations are among the most practical synthetic methods for the selective reduction of functional groups. Cheap and readily available dihydrogen (H2) equivalents are highly desirable for catalytic transfer hydrogenations, as inevitably, waste is generated by the formal H2 source. Copper hydride catalysis generally relies on stoichiometric use of waste-generating hydrosilanes. Here, we demonstrate that simple alcohols can be employed as H2 equivalents in stereoselective alkyne semihydrogenations, prototypical copper hydride-catalysed transformations.

History

Email Address of Submitting Author

johannes.teichert@chem.tu-berlin.de

Institution

Technische Universit├Ąt Berlin

Country

Germany

ORCID For Submitting Author

0000-0003-1043-8092

Declaration of Conflict of Interest

no conflict of interest

Exports

Logo branding

Exports