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Unexpected Nickel Complex Speciation Unlocks Alternative Pathways for the Reactions of Alkyl Halides with dppf-Nickel(0)

preprint
submitted on 22.05.2020 and posted on 26.05.2020 by Megan Greaves, Thomas O. Ronson, Guy Lloyd-Jones, Feliu Maseras, Stephen Sproules, David Nelson
The mechanism of the reactions between dppf-Ni0 complexes and alkyl halides has been investigated using kinetic and mechanistic experiments and DFT calculations. The active species is [Ni(dppf)2], which undergoes a halide abstraction reaction with alkyl halides and rapidly captures the alkyl radical that is formed. The yields in prototypical nickel-catalysed Kumada cross-coupling reactions are shown to be improved by the addition of free phosphine ligands

Funding

Industrial CASE Account - University of Strathclyde 2017

Engineering and Physical Sciences Research Council

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History

Email Address of Submitting Author

david.nelson@strath.ac.uk

Institution

University of Strathclyde

Country

Scotland

ORCID For Submitting Author

0000-0002-9461-5182

Declaration of Conflict of Interest

No conflicts of interest.

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