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Unexpected Formation of Hexasubstituted Arenes Through a Twofold Palladium-Mediated Ligand Arylation

preprint
submitted on 06.08.2019 and posted on 07.08.2019 by Corin Wagen, Bryan T. Ingoglia, Stephen L. Buchwald

A rearrangement reaction of biarylphosphine-supported Pd(II) complexes was employed to synthesize 1,3,5-triaryl 2,4,6-triisopropylbenzene compounds, a class of molecules that has not previously been reported. The strain of the central hexasubstituted ring was investigated via X-ray crystallography.


Funding

NIH R35GM122483

NSF CHE 0946721

History

Email Address of Submitting Author

cwagen@mit.edu

Institution

Massachusetts Institute of Technology

Country

United States of America

ORCID For Submitting Author

0000-0003-3315-3524

Declaration of Conflict of Interest

The authors declare the following competing financial interest(s): MIT has patents on some of the ligands and precatalysts used in this work, from which S.L.B. and former coworkers receive royalty payments.

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