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submitted on 14.11.2019 and posted on 25.11.2019by Osamah Alghazwat, Somayeh Talebzadeh, Yi Liao
Carbon monoxide releasing molecules (CORMs) have
been intensively studied in the past decade due to the therapeutic effects of
CO. The potential to control the release of CO to a specific target is one of the
major advantages of CORM. In this work an ultrasound responsive micelle with
pluronic as the shell and CORM-2 as the core were developed. The micelle
released CO in the presence of cysteine. After the CO release stopped, applying
ultrasound to the micelle suspension produced additional CO. About 1/3 of total
CO can be controllably released by ultrasound. The mechanism of the ultrasound
induced CO release is interpreted by the reaction between cysteine and CORM-2
inside the micelle.