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Tuning the Thermogelation and Rheology of Poly(2-Oxazoline)/poly(2-Oxazine)s Based Thermosensitive Hydrogels for 3D Bioprinting.

preprint
submitted on 24.04.2021, 16:44 and posted on 26.04.2021, 14:19 by Malik Salman Haider, Taufiq Ahmad, Mengshi Yang, Chen Hu, Lukas Hahn, Philipp Stahlhut, Jürgen Groll, Robert Luxenhofer
As one kind of smart material, thermogelling polymers find applications in biofabrication, drug delivery and regenerative medicine. Here, we reported on a novel thermosensitive hydrogel which can be 3D printed using extrusion based printing. Gel strength was found around 3kPa storage modulus with pronounced shear thinning and rapid recovery after stress. Addition of clay nanoparticles (Laponite XLG) improved the rheological profile further. Human adipose derived stem cells were added to the hydrogel matrix, which remained fully viable after printing. Therefore, the presented materials adds to the available material toolbox for 3D bioprinting.

Funding

Higher Education Commission of Pakistan

Deutscher Akademischer Austauschdienst

Deutsche Forschungsgemeinschaft

History

Email Address of Submitting Author

robert.luxenhofer@helsinki.fi

Institution

University of Helsinki

Country

Finland

ORCID For Submitting Author

0000-0001-5567-7404

Declaration of Conflict of Interest

R.L. is listed as inventor on a patent pertinent to some materials in the present work. The authors declare no other competing financial interest.

Version Notes

first version submitted for peer review

Exports