ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
2020_ChemArxiv_Aug18_GeraDasgupta.pdf (2.11 MB)
0/0

Trapping an Elusive Fe(IV)-Superoxo Intermediate Inside a Self-Assembled Nanocage at Room Temperature

preprint
submitted on 18.08.2020 and posted on 19.08.2020 by Rahul Gera, Kundan K. Singh, Sayam SenGupta, Jyotishman Dasgupta
Natural metalloenzymes stabilize reactive intermediates through specific metal-substrate interactions in protein confinement. Using the structural blueprint of enzyme pockets it is possible to trap elusive intermediates inside molecular cavities. Here we demonstrate room temperature trapping of a rare yet stable Fe(IV)-superoxo [FeIV(O2)-bTAML] intermediate subsequent to dioxygen binding at the Fe(III) site of a (Et4N)2[FeIII(Cl)(bTAML)] catalyst confined inside the hydrophobic interior of a water-soluble Pd6L412+ nanocage.

Funding

DAE grant number Project No. 12-R&D-TFR-5.10-0100

History

Email Address of Submitting Author

dasgupta@tifr.res.in

Institution

Tata Institute of Fundamental Research, Mumbai

Country

India

ORCID For Submitting Author

0000-0003-4607-653X

Declaration of Conflict of Interest

Authors report no conflict of interest.

Version Notes

Original Version

Exports