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Transforming Growth Factor-β1 Is Resilient to Heat-Induced Conformational Change

preprint
submitted on 24.03.2021, 07:12 and posted on 24.03.2021, 13:25 by Rui Tang, Kaelyn Gasvoda, Jacob Rabin, Eben Alsberg
TGF-beta1 is an essential signaling protein in numerous important biological pathways. Traditionally, TGF-beta1 is considered a sensitive protein so that this protein was handled with extreme care for production and storage. TGF-beta1 also exists in foods from animal sources, such as milk, and has been proven to be absorbed through ingestion. The food sourced TGF-beta1 was also not considered active after normal food processing, such as heating. Our research calls into question these concepts and encourages the research community to reconsider the activity of heated TGF-beta1 for both biomedical and nutrition applications.

Funding

Driving Tissue Formation by Inductive Stem Cell Sheet Technology

National Institute of Arthritis and Musculoskeletal and Skin Diseases

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Mechanical regulation of endochondral bone regeneration

National Institute of Arthritis and Musculoskeletal and Skin Diseases

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Engineering a Self-assembled, multi-tissue Tracheal Replacement

National Institute of Biomedical Imaging and Bioengineering

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CWRU- Cardiovascular Research Training Program

National Heart Lung and Blood Institute

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Training Program in Lung Biology and Pathobiology

National Heart Lung and Blood Institute

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History

Email Address of Submitting Author

ealsberg@uic.edu

Institution

the University of Illinois at Chicago

Country

United States

ORCID For Submitting Author

0000-0002-3487-4625

Declaration of Conflict of Interest

The authors declare no competing financial interest.

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