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Towards the Development of a Targeted Albumin-Binding Radioligand for Theranostic Applications: Synthesis, Radiolabelling and Preliminary In Vivo Studies

preprint
submitted on 22.07.2020 and posted on 22.07.2020 by Cathryn H.S. Driver, Thomas Ebenhan, Jan Rijn Zeevaart, Roger Hunter, Iqbal Parker, Zoltan Szucs
GluCAB is a newly synthesised macrocyclic radioligand designed to bind in vivo to albumin (HSA) for the purpose of development as a dual-targeting oncological theranostic agent. Subsequent to its synthesis and 64Cu-radiolabelling, this radioligand has show a prolonged circulation time in healthy mice but with appropriate systemic clearance within 24 h. This radioligand meets the criteria to be further investigated for tumour targeting and uptake.

History

Email Address of Submitting Author

cathryn.driver@necsa.co.za

Institution

South African Nuclear Energy Corporation

Country

South Africa

ORCID For Submitting Author

0000-0001-8562-1639

Declaration of Conflict of Interest

No conflict of interest to declare

Version Notes

Full Article revised to remove Journal watermark and header

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