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This report covers academic small-molecule drug
development with a view to distilling guidelines. The first section covers research
productivity feeding into commercial development before reviewing the literature on statistics of academic development It then considers differences between probes
and drugs before discussing the role of author guidelines in medicinal chemistry
and pharmacology journals. Resources for comprehensive compound and target
cross-checking are then covered followed by comparisons between public and commercial
databases including case studies of selected compounds. It concludes with an
outline of new scientific developments that could increase the success rate of academic