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Total Synthesis of Putative Structure of Asperipin-2a and Stereochemical Reassignment
preprintsubmitted on 04.08.2020, 02:07 and posted on 04.08.2020, 12:44 by SADEGH SHABANIBALAJADEH, JONATHAN WHITE, Craig Hutton
The total synthesis of the putative structure of asperipin-2a is described. The synthesis features ether cross-links between the phenolic oxygen of Tyr6 and β position of Tyr3 and the phenolic oxygen of Tyr3 and the β position of Hpp1 in the unique 17- and 14-membered bicyclic structure of asperipin-2a, respectively. The synthesized putative structure does not match the natural product and a stereochemical reassignment is postulated.