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manuscript.pdf (1.57 MB)
Time-dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE-active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation
Preprints are manuscripts made publicly available before they have been submitted for formal peer review and publication. They might contain new research findings or data. Preprints can be a draft or final version of an author's research but must not have been accepted for publication at the time of submission.
submitted on 14.09.2019 and posted on 17.09.2019by Qiyao Li, Ying Li, Tianliang Min, Junyi Gong, Lili Du, Kai LI, David Lee Phillips, Junkai Liu, Jacky W. Y. Lam, Herman H.-Y. Sung, Chun Loong Ho, Ian Duncan Williams, Ryan Tsz Kin Kwok, Jianguo Wang, Ben Zhong Tang
Pathogen infection and
cancer are the two major human health problems. In this work, we achieved an
organic salt photosensitizer (PS), called 4TPA-BQ with aggregation-induced
emission feature via one-step
reaction. Owing to the aggregation-induced reactive oxygen species generation
effect and sufficient small ΔEST,
4TPA-BQ shows a satisfactorily high 1O2 generation
efficiency of 97.8%. In vitro and in vivo
experiments confirmed that 4TPA-BQ exhibited potent photodynamic antibacterial
performance against ampicillin-resistant Escherichia
coli with good biocompatibility in a short time (15 min). When the
incubation time persisted long enough (12 h), cancer cells were ablated
efficiently, leaving normal cells essentially unaffected. This is the first reported
time-dependent fluorescence-guided photodynamic therapy in one individual PS
for ordered and multiple targeting by varying the external conditions. This can
update the design principle of efficient PSs in potential clinical applications.