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Time-dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE-active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation

preprint
submitted on 14.09.2019 and posted on 17.09.2019 by Qiyao Li, Ying Li, Tianliang Min, Junyi Gong, Lili Du, Kai LI, David Lee Phillips, Junkai Liu, Jacky W. Y. Lam, Herman H.-Y. Sung, Chun Loong Ho, Ian Duncan Williams, Ryan Tsz Kin Kwok, Jianguo Wang, Ben Zhong Tang
Pathogen infection and cancer are the two major human health problems. In this work, we achieved an organic salt photosensitizer (PS), called 4TPA-BQ with aggregation-induced emission feature via one-step reaction. Owing to the aggregation-induced reactive oxygen species generation effect and sufficient small ΔEST, 4TPA-BQ shows a satisfactorily high 1O2 generation efficiency of 97.8%. In vitro and in vivo experiments confirmed that 4TPA-BQ exhibited potent photodynamic antibacterial performance against ampicillin-resistant Escherichia coli with good biocompatibility in a short time (15 min). When the incubation time persisted long enough (12 h), cancer cells were ablated efficiently, leaving normal cells essentially unaffected. This is the first reported time-dependent fluorescence-guided photodynamic therapy in one individual PS for ordered and multiple targeting by varying the external conditions. This can update the design principle of efficient PSs in potential clinical applications.

History

Email Address of Submitting Author

qlibk@connec.ust.hk

Institution

The Hong Kong University of Science and Technology

Country

Hong Kong

ORCID For Submitting Author

0000-0002-4472-1534

Declaration of Conflict of Interest

no conflict of interest

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