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Ti-Catalyzed Ring-Opening Oxidative Amination of Methylenecyclopropanes with Diazenes

preprint
submitted on 12.05.2020 and posted on 14.05.2020 by Evan Beaumier, Amy Ott, Xuelan Wen, Zachary Davis-Gilbert, T. Alexander Wheeler, Joseph Topczewski, Jason Goodpaster, Ian Tonks

The ring-opening oxidative amination of methylenecyclopropanes (MCPs) with diazenes catalyzed by py3TiCl2(NR) complexes is reported. This reaction selectively generates branched α-methylene imines as opposed to linear α,β-unsaturated imines, which are difficult to access via other methods

Funding

Ti-Catalyzed Nitrene Transfer Reactions

National Institute of General Medical Sciences

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Chiral ?,?-Disubstituted Amine Synthesis by Dynamic Kinetic Resolution

National Institute of General Medical Sciences

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Upgrade of a 500 MHz NMR Spectrometer for Applications in Biomedical Research

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Alfred P Sloan Foundation

DE-AC02-05CH11231

History

Email Address of Submitting Author

itonks@umn.edu

Institution

University of Minnesota

Country

United States

ORCID For Submitting Author

0000-0001-8451-8875

Declaration of Conflict of Interest

No conflict of interest

Version Notes

This is version 1.

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