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The Virtual Circular Genome Model for Primordial RNA Replication

preprint
submitted on 23.08.2020 and posted on 25.08.2020 by Lijun Zhou, Dian Ding, Jack Szostak
Our manuscript describes a hypothesis for the replication of primordial RNA genomes by entirely nonenzymatic processes. Our proposal circumvents long standing problems such as the difficulty of copying long templates by nonenzymatic chemistry, the need for defined primers, and the so-called ‘last base addition problem’. Our hypothesis leads to surprising predictions, notably that the replication of an ensemble of oligonucleotides could be mediated by the template-directed extension of all oligos by as little as one nucleotide, on average. We propose experimental tests of our model, and discuss its implications for the origin of life.

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Email Address of Submitting Author

lzhou@molbio.mgh.harvard.edu

Institution

Mass General Hospital / Harvard University

Country

USA

ORCID For Submitting Author

0000-0002-0393-4787

Declaration of Conflict of Interest

no conflict of interest

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