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The Use of UiO-Type MOFs in Vapour Phase Soai Reactions
preprintsubmitted on 30.12.2020, 17:17 and posted on 31.12.2020, 09:21 by Giuesppe rotunno, Gurpreet Kaur, Andrea Lazzarini, Carlo Buono, Mohamed Amedjkouh
We report a novel vapour phase procedure to perform the Soai reaction in an absolute asymmetric synthesis fashion: the substrate is confined in the pores of the UiO-type MOFs, and vapour phase reactions with Zn(i-Pr)2 are performed in a sealed environment, Different MOFs lead to different outcomes in terms of enantiomeric excess, handedness of the product and reaction rate. This is one of the first examples of absolute asymmetric synthesis performed inside a MOF.