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The Interaction of Chondroitin Sulfate with a Lipid Monolayer Observed by Using Nonlinear Vibrational Spectroscopy

preprint
submitted on 10.03.2021, 18:19 and posted on 11.03.2021, 13:20 by Gergo Peter Szekeres, Szilvia Krekic, Rebecca L. Miller, Mark Mero, Kevin Pagel, Zsuzsanna Heiner

We present the first vibrational sum-frequency generation spectroscopic study of chondroitin sulfate (CS) interacting with dipalmitoyl phosphatidylcholine (DPPC) at the air-liquid interface. In the presence of Ca2+ and CS, the DPPC headgroups reoriented, while the tail orientations remained mostly unchanged. The results further suggest a chiral secondary structure for CS.

Funding

DFG GSC 1013 SALSA

DFG 372486779

DFG 1340

DNFR107

CF20-0412

ERC 899687 (HS-SEQ)

German Academic Exchange Service (DAAD)

History

Email Address of Submitting Author

heinerzs@hu-berlin.de

Institution

School of Analytical Sciences Adlershof, Humboldt-Universität zu Berlin

Country

Germany

ORCID For Submitting Author

0000-0002-9458-9164

Declaration of Conflict of Interest

No conflicts to declare

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