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The Chirality of Yariv Reagent Aggregates Correlates with AGP–binding Ability
preprintsubmitted on 28.10.2020, 15:35 and posted on 29.10.2020, 11:23 by Raghuraj Hoshing, Blaise W Leeber III, Helene Kuhn, David Caianiello, Brandon Dale, Michael Saladino, Robert Lusi, Natalie Palaychuk, Sarah Weingarten, Amit Basu
Yariv reagents are glycosylated triphenylazo dyes, some of which bind to the polysaccharide component of arabinogalactan proteins (AGPs), proteoglycans found in plant cell walls. However, the exact reason for the selectivity in the presence/absence of AGP binding ability among Yarivs remains unknown. The Yariv reagents are known to form supramolecular aggregates in solution. We use circular dichroism to show that the Yariv reagent aggregates possess helical chirality, and the AGP binding ability of the Yariv reagents is correlated to its helical chirality.