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YB-manuscript-chemrxiv.docx (763.63 kB)
The Breaking Beads Approach for Photocleavage from Solid Support
Preprints are manuscripts made publicly available before they have been submitted for formal peer review and publication. They might contain new research findings or data. Preprints can be a draft or final version of an author's research but must not have been accepted for publication at the time of submission.
submitted on 10.02.2020 and posted on 11.02.2020by yasmeen bakhatan, Israel Alshanski, Dana Grunhaus, Mattan Hurevich
polystyrene beads is a pivotal reaction for solid phase synthesis that relies on
photolabile linkers. The photocleavage, usually performed by batch irradiation,
suffers from incomplete and slow cleavage. To overcome these issues, continuous
flow and high-energy lamps are frequently used, but these setups are hazardous,
technically challenging, and expensive. We developed a photocleavage approach
that relies on a benchtop LED lamp and magnetic stirring. In this approach, we
crush the beads instead of keeping their integrity to increase the yield of
photocleavage. This approach proved very efficient for photocleavage of