The Aggregation of Striped Nanoparticles in Mixed Phospholipid Bilayers

17 December 2019, Version 2
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We have used molecular dynamics (MD) to study the interaction of ligand-functionalized nanoparticles (NPs) with striped configurations of hydrophobic and hydrophilic ligands with mixed bilayers. As such NPs have been considered a potential drug-delivery mechanism, it is important to consider the secondary effects the inclusion of such NPs may cause in the heterogeneous environment inside the lipid bilayer, which would give an insight into how to optimize the NP functionalization for the most efficient delivery. We show that NPs can aggregate by inducing raft-like formations around each NP, which allows the subsequent aggregation of the NPs which reduces the overall surface area of the line tension around each NP.

Keywords

Nanoparticle
Lipid BIlayer
Molecular Dynamics
Ligand-functionalized Nanoparticle
Mixed Bilayers
Lipid Rafts

Supplementary materials

Title
Description
Actions
Title
supplementary information
Description
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.