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Manuscript-2020.10.06.docx (1.07 MB)

Taming ROS: Mitochondria-Targeted AIEgen for Neuron Protection via Photosensitization-Triggered Autophagy

preprint
submitted on 23.10.2020, 07:39 and posted on 03.12.2020, 06:51 by Chao Chen, Ruoyao Zhang, Jianyu Zhang, Yufan Zhang, Haoke Zhang, Zaiyu Wang, Xiaolin Huang, Sijie Chen, Ryan Tsz Kin Kwok, Jacky W. Y. Lam, Dan Ding, Ben Zhong Tang

Oxidative damages lead to accumulated harmful wastes, which in turn aggravate the related diseases and ROS imbalance. Therefore, provoking the defense system against severe oxidation and maintaining ROS homeostasis are desired. Herein, we used a mitochondria-targeted aggregation-induced emission luminogen (AIEgen) as a phototherapy agent for neuron protection by virtue of its efficient ROS generation in aggregates and mitochondrial delivery. It is demonstrated that controllable ROS generation within mitochondria can trigger defensive autophagy against oxidative damages in neuron cells. This work not only verifies the concept that taming ROS can be used for cell protection, but also provides a promising method to trigger autophagy against destructive oxidation, displaying broad prospects for alleviating oxidation-related diseases and promoting cell-based therapy.

History

Email Address of Submitting Author

chenchao@ust.hk

Institution

Hong Kong University of Science and Technology

Country

China

ORCID For Submitting Author

0000-0001-7298-6575

Declaration of Conflict of Interest

No

Exports