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Paper_Seema_2.pdf (216.28 kB)

T Cell Epitope-Based Vaccine Design for Pandemic Novel Coronavirus 2019-nCoV

revised on 02.04.2020, 01:20 and posted on 03.04.2020, 12:26 by Seema Mishra
Immunoinformatics approach has been used to identify potential T cell epitopes from structural and non-structural proteins for immunotherapy against novel coronavirus 2019-nCoV across populations Two different prediction algorithms, NetCTLpan and Pickpocket were used to generate consensus epitopes against HLA supertypes. All of the 57 epitopes identified had no similarity/identity with the human proteome thus preventing crossreactivity. Many of these epitopes formed a tight cluster around consensus sequences

MGYINVFAFPFTIYSLLLC and KVSIWNLDYIINLI across proteins and alleles. These should be urgently tested in in-vitro MHC binding and T cell assays before being tried as vaccines to further prevent pandemic due to this lethal coronavirus.


Email Address of Submitting Author


University of Hyderabad



ORCID For Submitting Author

Declaration of Conflict of Interest

This author declares no conflict of interest