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Systematic and Quantitative Structure-Property Relationships of Polymeric Medical Nanomaterials: From Systematic Synthesis and Characterization to Computer Modeling and Nano-Bio Interaction and Toxicity

preprint
submitted on 15.05.2020 and posted on 18.05.2020 by kegang Liu, xueya wang, Xiaochun Li-Blatter, Marc P. Wolf, Patrick Hunziker
Nanomaterials are suitable for numerous applications in medicine. Building on their design versatility, they enable construction of novel targeted therapies, including personalized medicine. However, the freedom of design entails a multitude of parameters, which have to be optimized for application in nanomedicine.
Currently,nonamaterial assortment is mainly anecdotal, non-systematic and non-representative. In contrast to the mostly oligo-disciplinary nature of many publications, we here present a systematic and comprehensive multidisciplinary approach to chemical synthesis, physicochemical characterization, computer modeling, and in vitro and in vivo exploration of nanomaterials that may be suited for medical application. Specially, we design and synthesize a library of amphiphilic oxazoline/siloxane block co-polymers with varying chain lengths and different end groups. In this regard, the computer modeling of the current polymer library is contributing to further optimization of these nanomaterials in a fast and reliable, and efficient way. In conclusion, these outstandingly versatile and non-toxic polymers can be synthesized rapidly and easily and self-assemble to polymeric micelles in aqueous solutions, thus rendering them amenable for numerous medical diagnostic and therapeutic applications

Funding

Swiss National Science Foundation

History

Email Address of Submitting Author

kegang.liu@unibas.ch

Institution

University hospital Basel, University of Basel

Country

Switzerland

ORCID For Submitting Author

0000-0001-9105-9590

Declaration of Conflict of Interest

The authors declare no competing financial interest.

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