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Synthesis of Tertiary Amines by Direct Brønsted Acid Catalyzed Reductive Amination

preprint
submitted on 20.04.2020 and posted on 21.04.2020 by Thanh Vinh Nguyen, Mohanad A. Hussein, An Huy Dinh, Vien Huynh
Tertiary amines are ubiquitous and valuable compounds in synthetic chemistry, with a wide range of applications in organocatalysis, organometallic complexes, biological processes and pharmaceutical chemistry. One of the most frequently used pathways to synthesize tertiary amines is the reductive amination reaction of carbonyl compounds. Despite developments of numerous new reductive amination methods in the past decades, this reaction generally requires non-atom-economic processes with harsh conditions and toxic transition-metal catalysts. Herein we report simple yet practical protocols using triflic acid as catalyst to efficiently promote direct reductive amination reactions of carbonyl compounds on a broad ranges of substrates. Applications of this new method to generate valuable heterocyclic frameworks and polyamines are also included.

Funding

DP200100063 (Australian Research Council - Discovery Project)

Novel organic architectures and functional materials from tropylium ions

Australian Research Council

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History

Email Address of Submitting Author

t.v.nguyen@unsw.edu.au

Institution

University of New South Wales, Sydney

Country

Australia

ORCID For Submitting Author

0000-0002-0757-9970

Declaration of Conflict of Interest

No conflicts of interest.

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