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Synthesis of Quinolinone Alkaloids via Aryne Insertions into Unsymmetric Imides in Flow

preprint
submitted on 23.10.2018 and posted on 24.10.2018 by Johannes Schwan, Merlin Kleoff, Bence Hartmayer, Philipp Heretsch, Mathias Christmann
A general strategy for the synthesis of 3,4-dioxygenated quinolin-2-one natural products is reported. The key
step is a regioselective insertion of arynes into unsymmetric imides in flow.

History

Email Address of Submitting Author

mathias.christmann@fu-berlin.de

Institution

Freie Universität Berlin

Country

Germany

ORCID For Submitting Author

0000-0001-9313-2392

Declaration of Conflict of Interest

There is no conflict of interest

Version Notes

Final version before submission

Exports