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Synthesis of N-Alkylpyridin-4-ones and Thiazolo[3,2-a]pyridin-5-ones Through Pummerer-Type Reactions

preprint
revised on 20.06.2019 and posted on 20.06.2019 by Jingjia Huang, Gang Hu, Shaoyu An, Dongding Chen, Minglei Li, Pingfan Li
N-alkylated 4-pyridones were obtained through a one-pot procedure involving either normal or interrupted Pummerer reactions between triflic anhydride activated sulfoxides and 4-fluoropyridine derivatives, followed by hydrolysis. On the other hand, triflic anhydride activated benzyl 6-fluoro-2-pyridyl sulfoxide could react with alkenes or alkynes to afford thiazolo[3,2-a]pyridin-5-ones, via the pyridinium salt intermediates.

Funding

National Natural Science Foundation of China (21402005)

Fundamental Research Funds for the Central Universities (XK-1802-6, 12060093063)

History

Email Address of Submitting Author

lipf@mail.buct.edu.cn

Institution

Beijing University of Chemical Technology

Country

China

ORCID For Submitting Author

0000-0002-0056-9243

Declaration of Conflict of Interest

no conflict of interest

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