ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
2 files
0/0

Synthesis of High Molecular Weight Chitosan from Chitin by Mechanochemistry and Aging

preprint
revised on 30.01.2019 and posted on 30.01.2019 by Thomas Di Nardo, Caroline Hadad, Albert Nguyen Van Nhien, Audrey Moores
Chitosan can be obtained from the deacetylation of chitin. This process is however difficult and usually accompanied by depolymerization, affording low molecular weight chitosan. We report a novel path, relying on a combination of mechanochemitry and aging, to afford high molecular weight chitosan with minimal use of energy and solvent. This method is versatile and applicable to a number of chitin sources, including crude crustaceans and insect shells, yielding deacetylation up to 98% and remarkably high molecular weights. Chitin deacetylation was measured by magic angle spinning nuclear magnetic resonance and molecular weight by viscometry. This process affords chitosan in a safer fashion and with less materials and energy usage than the classic hydrothermal one.

Funding

Natural Science and Engineering Research Council of Canada Discovery Grant & Discovery Accelerator programs, the Canada Foundation for Innovation (CFI), the Canada Research Chairs (CRC), the Fonds de Recherche du Québec – Nature et Technologies (FRQNT) Equipe program, the Centre for Green Chemistry and Catalysis (CGCC), McGill University

History

Email Address of Submitting Author

audrey.moores@mcgill.ca

Institution

McGill University

Country

Canada

ORCID For Submitting Author

0000-0003-1259-913X

Declaration of Conflict of Interest

There is no conflict of interest associated with this research

Version Notes

In this version, we added energy comparison between our method and solvothermal ones. We also changed the presentation of the MW discussion to focus on viscosity parameters instead

Exports