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Synthesis of 3-Substituted Pyrrolidines via Palladium-Catalysed Hydroarylation

preprint
revised on 02.11.2018, 12:14 and posted on 02.11.2018, 12:22 by Joe Sweeney, Julien Doulcet, Bimod Thapa
Metal-catalysed reactions have revolutionised synthetic chemistry, allowing access to unprecedented molecular architectures with powerful properties and activities. Nonetheless, some transformations remain sparse in number, or out of reach, even with the diverse modern catalytic chemical arsenal, including bimolecular alkene hydroarylation reactions. We report here the first palladium-catalysed alkene hydroarylation to give 3-aryl pyrrolidines, a class of small molecule with potency in a diverse range of biological scenarios. The process has broad substrate scope and can be used to directly deliver drug-like molecules in a single step from readily available precursors.

History

Email Address of Submitting Author

j.sweeney1@lancaster.ac.uk

Institution

Lancaster University

Country

United Kingdom

ORCID For Submitting Author

0000-0001-7593-9598

Declaration of Conflict of Interest

No conflict of interest

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