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Kharas_ChemRxiv_v10.pdf (280.15 kB)

Synthesis and styrene copolymerization of novel fluoro-iodo, trifluoromethyl, and trifluoromethoxy ring-substituted isobutyl phenylcyanoacrylates

revised on 06.10.2020, 20:35 and posted on 13.10.2020, 15:38 by Alessandra Cimino, Amaan M. Azeemullah, Danielle E. Comp, Sydney C. Hunt, Madison M. Janakis, Sonia S. Khan, Patryk Labedz, Christopher Lee, Sara M. Rocus, William S. Schjerven, Gregory Kharas

Novel fluoro-iodo, trifluoromethyl, and trifluoromethoxy ring-substituted isobutyl phenylcyanoacrylates, RPhCH=C(CN)CO2CH2CH(CH3)2 (where R is 2-fluoro-5-iodo, 2-fluoro-6-iodo, 2-trifluoromethyl, 3-trifluoromethyl, 4-trifluoromethyl, 2-trifluoromethoxy, 3-trifluoromethoxy, 4-trifluoromethoxy) were synthesized by the piperidine catalyzed Knoevenagel condensation of ring-substituted benzaldehydes and isobutyl cyanoacetate and characterized by CHN analysis, IR, 1H and 13C NMR. The acrylates were copolymerized with styrene in solution with radical initiation (ABCN) at 70C. The compositions of the copolymers were calculated from nitrogen analysis.


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DePaul University



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