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Synthesis and Breakdown of the Universal Precursors to Biological Metabolism Promoted by Ferrous Iron

submitted on 08.10.2018, 17:05 and posted on 09.10.2018, 12:04 by Kamila B. Muchowska, Sreejith Jayasree VARMA, Joseph Moran
How core biological metabolism initiated and why it uses the intermediates, reactions and pathways that it does remains unclear. Life builds its molecules from CO2 and breaks them down to CO2 again through the intermediacy of just five metabolites that act as the hubs of biochemistry. Here, we describe a purely chemical reaction network promoted by Fe2+ in which aqueous pyruvate and glyoxylate, two products of abiotic CO2 reduction, build up nine of the eleven TCA cycle intermediates, including all five universal metabolic precursors. The intermediates simultaneously break down to CO2 in a life-like regime resembling biological anabolism and catabolism. Introduction of hydroxylamine and Fe0 produces four biological amino acids. The network significantly overlaps the TCA/rTCA and glyoxylate cycles and may represent a prebiotic precursor to these core metabolic pathways.


Email Address of Submitting Author


University of Strasbourg, CNRS, ISIS & icFRC



ORCID For Submitting Author


Declaration of Conflict of Interest

No conflict of interest.

Version Notes

This is version 1.