These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
Synthesis, Characterization and Biological Evaluation of Novel Tetrasubsituted Imidazole Compounds
preprintsubmitted on 15.06.2020, 08:55 and posted on 17.06.2020, 06:01 by khurram shahzad, Faheem Abbas, DIGVIJAY PANDEY, Sanila Ajmal, Mudassar Khadim, Muhammad usman tahir
A new class of tetrasubsituted imidazole based compounds were synthesized using multicomponent one pot synthesis scheme through cyclocondensation reaction of benzil, aromatic primary amines, aldehydes and ammonium acetate in glacial acetic acid. The synthesized compounds have been analyzed and characterized by melting point, color, conductivity method, CHN analysis, FT-IR and UV-Visible. The reaction proceeding was examined by TLC after regular intervals of period. To test biological activity, the synthesized compounds have been examined against various bacterial strains. From the analysis of the antibacterial activity of these synthesized compounds demonstrated that all three imidazole compounds have considerable to significant activity against the strains, and compound K2 was found potent comparatively.