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Synthesis, Characterisation and Cytotoxic Activity Evaluation of New Metalsalen Complexes Based on the 1,2-bicyclo[2.2.2]octane Bridge

preprint
submitted on 04.02.2020 and posted on 05.02.2020 by Pierre Milbeo, François Quintin, Laure Moulat, Claude Didierjean, Jean Martinez, Xavier Bantreil, Monique Calmès, Frédéric Lamaty
Diaminobicyclo[2.2.2]octane was used as starting material for the preparation, in solution or in a ball-mill, of a salen ligand. Five metal salen complexes were prepared in high yield and their cytotoxic activities were evaluated against HCT116 cell lines. Original manganese salen complex displayed the highest activity with a potency 16 fold higher than the one of cisplatin, demonstrating the benefit of the bridging backbone, compared to other salen systems. An alternative preparation route for this complex by mechanochemistry was also performed.

Funding

CNRS, MENESR

History

Email Address of Submitting Author

frederic.lamaty@umontpellier.fr

Institution

Université de Montpellier

Country

France

ORCID For Submitting Author

0000-0003-2213-9276

Declaration of Conflict of Interest

No conflict of interest

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