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Suzuki-Miyaura Cross Coupling towards 4-amino biphenyl intermediates.pdf (338.92 kB)
Suzuki-Miyaura Cross-Coupling Towards 4-Amino Biphenyl Intermediates
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submitted on 10.07.2019 and posted on 10.07.2019by Tomasz Jastrząbek, Artur Ulikowski, Rafał Lisiak
The preparation of biphenyl derivatives bearing amino groups via direct cross-coupling reaction is being widely explored due to its importance for many branches of the chemical industry. One of the necessary components for such a transformation are halogenated arenes. In order to make the process more economical, we focus on inexpensive and easily available aryl chlorides which usually are not considered reagents of choice for catalytic couplings. In the following short communication, we report the results of the coupling of relatively unreactive chloroaniline with a fluorinated phenylboronic acid leading to the corresponding aminobiphenyl.