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Suzuki-Miyaura Cross Coupling towards 4-amino biphenyl intermediates.pdf (338.92 kB)

Suzuki-Miyaura Cross-Coupling Towards 4-Amino Biphenyl Intermediates

preprint
submitted on 10.07.2019 and posted on 10.07.2019 by Tomasz Jastrząbek, Artur Ulikowski, Rafał Lisiak
The preparation of biphenyl derivatives bearing amino groups via direct cross-coupling reaction is being widely explored due to its importance for many branches of the chemical industry. One of the necessary components for such a transformation are halogenated arenes. In order to make the process more economical, we focus on inexpensive and easily available aryl chlorides which usually are not considered reagents of choice for catalytic couplings. In the following short communication, we report the results of the coupling of relatively unreactive chloroaniline with a fluorinated phenylboronic acid leading to the corresponding aminobiphenyl.

History

Email Address of Submitting Author

rafal.lisiak@selvita.com

Institution

Selvita Services

Country

Poland

ORCID For Submitting Author

0000-0002-1314-7082

Declaration of Conflict of Interest

None

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