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ion pair September 26th.pdf (2.05 MB)

Superelectrophilic Aluminum(III)-Ion Pairs Promote a Distinct Reaction Path for Carbonyl-Olefin Metathesis of Medium-Sized Rings

preprint
submitted on 27.09.2019 and posted on 30.09.2019 by Rebecca Watson, Ashlee J. Davis, Jessica L. Gomez-Lopez, Daniel Nasrallah, Corinna Schindler
We describe the development of a new catalyst system for carbonyl-olefin ring-closing metathesis reactions that relies on Lewis acidic superelectrophiles and significantly expands the current scope of this transformation to medium-sized rings.
Importantly, these superelectrophiles are shown to promote carbonyl-olefin metathesis via a distinct and unprecedented mechanism.

Funding

We thank the NIH/National Institute of General Medical Sci-ences (R01-GM118644), the Alfred P. Sloan Foundation, the David and Lucile Packard Foundation and the Camille and Hen-ry Dreyfus Foundation for financial support. R.B.W. thanks the National Science Foundation for a predoctoral fellowship. J.L.G.-L. thanks CONACyT for a postdoctoral fellowship.

History

Email Address of Submitting Author

corinnas@umich.edu

Institution

University of Michigan

Country

United States

ORCID For Submitting Author

0000-0003-4968-8013

Declaration of Conflict of Interest

No conflict of interest

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