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ion pair September 26th.pdf (2.05 MB)
Superelectrophilic Aluminum(III)-Ion Pairs Promote a Distinct Reaction Path for Carbonyl-Olefin Metathesis of Medium-Sized Rings
Preprints are manuscripts made publicly available before they have been submitted for formal peer review and publication. They might contain new research findings or data. Preprints can be a draft or final version of an author's research but must not have been accepted for publication at the time of submission.
We describe the development of a new catalyst system for carbonyl-olefin ring-closing metathesis reactions that relies on Lewis acidic superelectrophiles and significantly expands the current scope of this transformation to medium-sized rings.
Importantly, these superelectrophiles are shown to promote carbonyl-olefin metathesis via a distinct and unprecedented mechanism.
We thank the NIH/National Institute of General Medical Sci-ences (R01-GM118644), the Alfred P. Sloan Foundation, the David and Lucile Packard Foundation and the Camille and Hen-ry Dreyfus Foundation for financial support. R.B.W. thanks the National Science Foundation for a predoctoral fellowship. J.L.G.-L. thanks CONACyT for a postdoctoral fellowship.