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Sulfamides Direct Radical-Mediated Chlorination of Aliphatic C–H Bonds

preprint
revised on 10.07.2019 and posted on 11.07.2019 by Melanie Short, Mina Shehata, Matthew Sanders, Jennifer Roizen
Sulfamides guide intermolecular chlorine transfer to gamma-C(sp3) centers. This unusual position-selectivity arises because accessed sulfamidyl radical intermediates engage in otherwise rare 1,6-hydrogen-atom transfer processes. The disclosed chlorine-transfer reaction relies on a light-initiated radical chain-propagation mechanism to oxidize C(sp3)-H bonds.

Funding

NSF DCG 1106401

XSEDE Startup Allocation TG-CHE190001

U.S. Department of Education GAANN Fellowship, Award Num: P200A150114

History

Email Address of Submitting Author

j.roizen@duke.edu

Institution

Duke University

Country

United States

ORCID For Submitting Author

0000-0002-6053-5512

Declaration of Conflict of Interest

no conflict of interest

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