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Structures of LnmK a Bifunctional Acyltransferase/Decarboxylase with Substrate Analogs Reveals Basis for Selectivity and Stereospecificity
preprintsubmitted on 01.12.2020, 20:09 and posted on 04.12.2020, 11:27 by Lee M Stunkard, Benjamin J. Kick, Jeremy Lohman
We solved crystal structures of LnmK, which that carries out both acyltransfer and decarboxylation in polyketide synthase pathways. Our structures have substrate analogs bound that reveal interactions that likely occur with the substrate and allow modelling of conformational changes and intermediate states.