Structure-Based Screening of Potential Triterpenoids for Anti-Viral Activity Against SARS-CoV-2 and Related Coronaviruses
Triterpenoids possess valuable medicinal
properties ranging from anti-microbial to anti-cancer. Some of them were known
for their activity against HIV, Ebola and Influenza viruses. In this study, 108
triterpenoids were screened for its potential usage as anti-viral drug against
SARS-CoV-2, MERS and SARS coronaviruses, using molecular docking calculation
against their main proteases (Mpro) and ADME based drug-likeliness parameters.