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Structure-Based Screening of Potential Triterpenoids for Anti-Viral Activity Against SARS-CoV-2 and Related Coronaviruses

preprint
submitted on 31.07.2020 and posted on 03.08.2020 by Vijaya sundar Jeyaraj, Thiagarayaselvam Aarthy

Triterpenoids possess valuable medicinal properties ranging from anti-microbial to anti-cancer. Some of them were known for their activity against HIV, Ebola and Influenza viruses. In this study, 108 triterpenoids were screened for its potential usage as anti-viral drug against SARS-CoV-2, MERS and SARS coronaviruses, using molecular docking calculation against their main proteases (Mpro) and ADME based drug-likeliness parameters.

History

Email Address of Submitting Author

vijayscien@gmail.com

Institution

Indian Institute of Technology Madras

Country

India

ORCID For Submitting Author

0000-0003-2109-4299

Declaration of Conflict of Interest

There is no conflict of interest

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