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human pathogen Mycobacterium tuberculosis ( MTB) is indeed one of the
renowned important longtime infectious diseases that cause tuberculosis (TB).
Interestingly, MTB infection has become one of the world's leading causes of
human death. In trehalose synthase, the protein NCGM 946K2 146 found in MTB has
an important role. For carbohydrate transport and metabolism, trehalose
synthase is required. The protein is not clarified yet, however. In this
research, an in silico approach was therefore formulated for functional
and structural documentation of the uncharacterized protein NCGM946K2 146. Three
different servers, including the Modeller, the Phyre2, and the Swiss Model,
were used to evaluate the predicted tertiary structure. The top materials are
selected using structural evaluations conducted with the analysis of
Ramachandran Plot, Swiss-Model Interactive Workplace, Prosa-web, Verify 3D, and
Z scores. This analysis aimed to uncover the value of the NCGM946K2 146 protein
of MTB. This research will, therefore, improve our pathogenesis awareness and
give us a chance to target the protein compound.