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Schaper Charles DNA Steroid Symmetry 20200316.pdf (832.9 kB)
Structural Symmetry of DNA Nucleotides and Steroid Hormones
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DNA is comprised of important structural characteristics, which include the complementary base pairs of adenine-thymine (A-T) and cytosine-guanine (C-G) that serve to initiate and code for transcription and translation into amino acids. Recently, structural analysis of DNA performed in this lab indicated that each DNA nucleotide complementary base pair is in perfect correspondence with the structure of the steroid molecule and steroid hormones. Here, detailed structural analysis and illustrations are presented to clearly support and extend this fundamental finding. The structural illustrations indicate that the DNA Nucleotide base pairs can achieve perfect alignment with steroid hormones, such that each of its functional groups can be assigned a purpose for binding, stabilization, and transcription regulation. The relation of the missing third hydrogen bond for A-T and T-A, relative to the three hydrogen bonds of C-G and G-C, is clearly shown to be found through its coupling with the class of corticosteroids like cortisol that have an oxygen group perfectly positioned for interaction with the available functional group of thymine. Thus the intermolecular coupling by hydrogen bonding of Cortisol-Thymine produces a strong complex. Moreover, the structural analysis of the end group couplings to an ionic linkage element, Ca2+ or Mg2+, demonstrate interaction with both the DNA phosphates as well as the oxygen element within the sugar. The relationships confirm a structural association of cortisol-like steroid hormones with A-T and T-A and a structural association of testosterone-like steroid hormones for G-C and C-G. Synthetic steroids are assessed, including prednisolone and dexamethasone, to indicate consistency of the functional group interactions with the DNA base pairs, phosphate, and sugar groups to support and confirm direct binding and structural correspondence of steroid hormones to DNA Nucleotides.