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Stirring Peptide Synthesis to a New Level of Efficiency

preprint
revised on 13.04.2021, 19:29 and posted on 15.04.2021, 07:58 by Johnny N Naoum, Israel Alshanski, Guy Mayer, Poriah Strauss, Mattan Hurevich
In this work, a new setup that relies on fast stirring and heating was used to increase the diffusion of both reagents and solid support. we show that the combination of fast mixing and elevated temperature enables the acceleration of solid-phase peptide synthesis without using a large excess of reagents, providing a greener and accessible alternative to the state-of-the-art.

History

Email Address of Submitting Author

israel.alshanski@mail.huji.ac.il

Institution

Institute of Chemistry, The Hebrew University

Country

Israel

ORCID For Submitting Author

0000-0002-9310-1921

Declaration of Conflict of Interest

no conflict of interest

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