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Stirring Peptide Synthesis to a New Level of Efficiency
preprintrevised on 13.04.2021, 19:29 and posted on 15.04.2021, 07:58 by Johnny N Naoum, Israel Alshanski, Guy Mayer, Poriah Strauss, Mattan Hurevich
In this work, a new setup that relies on fast stirring and heating was used to increase the diffusion of both reagents and solid support. we show that the combination of fast mixing and elevated temperature enables the acceleration of solid-phase peptide synthesis without using a large excess of reagents, providing a greener and accessible alternative to the state-of-the-art.