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Stimuli-Responsive Cycloaurated ‘OFF-ON’ Switchable Anion Transporters

preprint
submitted on 03.05.2020 and posted on 05.05.2020 by Mohamed Fares, Xin Wu, Deepthi Ramesh, William Lewis, Paul Keller, Ethan Howe, Ricardo Pérez-Tomás, Philip Gale
Anion transporters have shown potential application as anti-cancer agents that function by disrupting homeostasis and triggering cell death. In this research article we report switchable anion transport by gold complexes of anion transporters that are ‘switched on’ in the presence of the reducing agent GSH by decomplexation of gold. GSH is found in higher concentrations in tumours than in healthy tissue and hence offers a strategy to target these systems to tumours.

Funding

Australian Research Council DP200100453

History

Email Address of Submitting Author

philip.gale@sydney.edu.au

Institution

The University of Sydney

Country

Australia

ORCID For Submitting Author

0000-0001-9751-4910

Declaration of Conflict of Interest

None

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