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Stimuli-Responsive Cycloaurated ‘OFF-ON’ Switchable Anion Transporters
preprintsubmitted on 03.05.2020, 04:20 and posted on 05.05.2020, 12:16 by Mohamed Fares, Xin Wu, Deepthi Ramesh, William Lewis, Paul Keller, Ethan Howe, Ricardo Pérez-Tomás, Philip Gale
Anion transporters have shown potential application as anti-cancer agents that function by disrupting homeostasis and triggering cell death. In this research article we report switchable anion transport by gold complexes of anion transporters that are ‘switched on’ in the presence of the reducing agent GSH by decomplexation of gold. GSH is found in higher concentrations in tumours than in healthy tissue and hence offers a strategy to target these systems to tumours.
Read the published paper
in Angewandte Chemie