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Stereoselective Oxidative Cyclization of N-Allyl Benzamides to Oxazolines
preprintsubmitted on 28.04.2021, 14:09 and posted on 29.04.2021, 13:02 by Ayham Abazid, Tom-Niklas Hollwedel, Boris Nachtsheim
This manuscript describes a highly enantioselective oxidative cyclization of N-Allyl Benzamides and derivatives thereof. This method uses a chiral triazole-based iodine catalyst to generate a hypervalent iodine compound in situ as the active catalytic species. Besides oxazolines, other N-heterocylces such as thiazolines, imidazolines as well as oxanines can be generated in high optical purities.