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submitted on 17.09.2020 and posted on 17.09.2020by Felix Reiners, Emanuel Joseph, Benedikt Nißl, Dorian Didier
Recent progress on four-membered ring building
blocks has led us to investigate the formation of non-natural azetidine-based
amino acids (Aze). A simple organometallic route was developed to access
unsaturated carboxylic acids, which were further engaged in metal catalyzed asymmetric
reduction. Functionalized Aze derivatives were finally employed in the
formation of small peptide chains.