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Stereoselective Access to Azetidine-Based α-Aminoacids and Applications to Small Peptides Synthesis

preprint
submitted on 17.09.2020 and posted on 17.09.2020 by Felix Reiners, Emanuel Joseph, Benedikt Nißl, Dorian Didier
Recent progress on four-membered ring building blocks has led us to investigate the formation of non-natural azetidine-based amino acids (Aze). A simple organometallic route was developed to access unsaturated carboxylic acids, which were further engaged in metal catalyzed asymmetric reduction. Functionalized Aze derivatives were finally employed in the formation of small peptide chains.

Funding

Fonds der chemischen Industrie (Liebig fellowship)

Deutsche Forschungsgemeinschaft (grant DI 2227/2-1 and Heisenberg fellowship DI 2227/4-1)

Ludwig-Maximilians Universität (LMU Excellence)

History

Email Address of Submitting Author

dorian.didier@cup.uni-muenchen.de

Institution

Ludwig-Maximilians Universität

Country

Germany

ORCID For Submitting Author

0000-0002-6358-1485

Declaration of Conflict of Interest

There are no conflicts of interest to declare.

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