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Steady-State Simulation of the Counter Current Liquid-Liquid Ex-Traction: Trimetozine Synthesis as a Case Study

submitted on 17.08.2019, 16:30 and posted on 19.08.2019, 19:46 by Zied Hosni, Ian Houson, Brahim Benyahia, Alastair Florence
The countercurrent liquid-liquid extraction is a crucial step in industrial process to purify and extract a compound of inter-ests for its impurities. This step requires generally challenging and time-consuming optimisation of numerous factors that affect the overall yield of extraction and the energy needed. The simulation of this process has been investigated in this pa-per using a Non-Random Two Liquid model implemented as a thermodynamic method in Aspen. The outcome of this model enables the evaluation of the partition coefficients of the different analytes of a mixtures at the different compart-ments of extraction platform. In addition, this steady-state model allows a more straightforward optimisation of the factors that drive the performance of extraction.


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Bristol University


United Kingdom

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